1、提取原蛋白质相互作用网络的所有节点

2、分别计算原蛋白质相互作用网络每个节点的度

3、从所有节点中选择具有最高度的节点，反复的添加边，直到它的度值等于原蛋白质相互作用网络该节点的度值

4、在为节点添加边时，从剩余节点中选择节点的方法是其度分布近似服从power-low分布

5、令t的值为零，则每个节点被选到的可能性都是相同的，由于在原蛋白质相互作用网络存在大量的低度节点，所以集散节点会优先连接低度节点。

这样创建的网络就为负相关蛋白质互作网络

-1, extract the original protein-protein interaction network of all nodes 2, respectively, the original calculation of protein-protein interaction network of each node of degree 3, from all nodes in the selection of the highest degree of node, add edge repeatedly until its value equal to the original protein-protein interaction network of the node value of 4, in order to add the edge node from the remaining nodes select the node is its degree distribution similar to obey power-low distribution of 5, so that the value of t is zero, each node was to the possibility of election are the same, as in the original protein-protein interaction network of the existence of a large number of low-level node, the node will be distributed so low priority to connect nodes. This network created for the negative correlation of protein interaction networks